UFC on ESPN 21: Brunson vs. Holland was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 20, 2021 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A middleweight bout between Derek Brunson and Kevin Holland served as the event headliner.

• Ultimate Fighting Championship
• Derek Brunson
• Kevin Holland
• Max Griffin
• Song Kenan
• Montserrat Ruiz
• Cheyanne Buys
• Adrian Yanez
• Gustavo Lopez