UFC 259: Błachowicz vs. Adesanya was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 6, 2021 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. The event was headlined by a UFC Light Heavyweight Championship bout between then champion Jan Błachowicz (also former KSW Light Heavyweight Champion) and former UFC Middleweight Champion Israel Adesanya.

• Ultimate Fighting Championship
• Jan Błachowicz
• Israel Adesanya
• Amanda Nunes
• Megan Anderson
• Aljamain Sterling
• Petr Yan
• Islam Makhachev
• Drew Dober