UFC on ESPN 49: Holm vs. Bueno Silva was a mixed martial arts event produced by the Ultimate Fighting Championship taking place on July 15, 2023, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A women's bantamweight bout between former UFC Women's Bantamweight Champion Holly Holm and Mayra Bueno Silva headlined the event.

• Ultimate Fighting Championship
• Mayra Bueno Silva
• Holly Holm
• Jack Della Maddalena
• Bassil Hafez
• Francisco Prado
• Ottman Azaitar
• Jun Yong Park
• Albert Duraev